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Home / Blog / Article
Patient Education6 min read

What to Expect During and After an Anti-VEGF Injection

Michael J. Elman, M.D.•December 15, 2025
What to Expect During and After an Anti-VEGF Injection

If you've been diagnosed with wet age-related macular degeneration (AMD), diabetic macular edema, or retinal vein occlusion, your retina specialist may recommend anti-VEGF injections (often referred to as eye injections or shots for macular degeneration). While the idea of an eye injection or receiving medication in the eye can be intimidating, understanding the process can help ease anxiety about your macular degeneration treatment or diabetic eye care.

What Is Anti-VEGF Therapy?

VEGF stands for vascular endothelial growth factor, a protein that stimulates the growth of abnormal blood vessels in the eye. These leaky vessels damage the retina and cause vision loss. Anti-VEGF medications — including Avastin, Lucentis, Eylea, and the newer Vabysmo — block this protein, slowing or stopping the damage.

Before the Injection

The procedure is performed in our office and typically takes less than 15 minutes. Your eye will be numbed with anesthetic drops, and the area around your eye will be cleaned with an antiseptic solution to prevent infection. Most patients report feeling only mild pressure during the injection.

During the Procedure

Using a very fine needle, your retina specialist injects a small amount of medication into the vitreous (the gel-like substance inside your eye). The injection itself takes only a few seconds. You may see floaters or feel mild pressure afterward — this is normal.

After the Injection

You can return to your normal activities almost immediately. Some patients experience:

  • Mild redness or irritation at the injection site
  • Temporary floaters or a small air bubble in vision
  • A scratchy sensation that resolves within a day

Serious complications are rare. Contact our office immediately if you experience severe pain, significant vision changes, or increasing redness.

How Often Will I Need Injections?

Treatment schedules vary by condition and medication. Many patients begin with monthly injections, then transition to a "treat-and-extend" schedule where the interval between injections is gradually increased based on your eye's response. Your doctor will create a personalized treatment plan.

Schedule Your Consultation

If you have questions about anti-VEGF therapy or have been referred for retinal treatment, contact Elman Retina Group at 410-686-3000 to schedule a consultation at any of our Baltimore-area offices.

#anti-VEGF#macular degeneration#diabetic retinopathy#treatment
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Questions About Your Eye Health?

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